The Centers for Disease Control and Prevention’s (CDC) state-based cancer programs play an indispensable role in the prevention, detection, and treatment of cancer. They save lives. Nearly half of cancer cases can be prevented and the substantial cost of the treatment of advanced disease could be reduced through the use of existing evidence-based prevention and early detection strategies supported by CDC’s cancer programs. For FY2021, OVAC requests funding levels that will enable these proven programs to accomplish even more.